Monoclonal gammopathies in the adult population of Finistere, France.

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Monoclonal gammopathies in the adult population of Finistère, France.

Three hundred and thirty-four monoclonal gammopathies were detected in the sera of 30 279 adults from Finistère. Monoclonal gammopathies (MG) are more common in Finistère than in Paris and their distribution is not homogeneous. IgG paraproteins are particularly common in the northeast of Finistère whereas IgM paraproteins are more common in the southwest. Family studies and the high degree of i...

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Monoclonal gammopathies

Clinical background The finding of a monoclonal immunoglobulin in the serum defines the so-called monoclonal gammopathy. Monoclonal components are homogeneus immunoglobulins whole (intact) or fragmented, produced by a single expanded plasma cell clone. MCs present unique physicochemical homogeneity, which is reflected in their immunological homogeinity. Immunological homogeinity by electrophore...

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The monoclonal gammopathies.

Each monoclonal protein (M-protein, or myeloma protein) consists of two heavy polypeptide chains of the same class and subclass and two light polypeptide chains of the same type. Electrophoresis on cellulose acetate membranes is satisfactory for screening, although agarose electrophoresis is more sensitive for detecting small M-proteins. Immunoelectrophoresis should be performed when myeloma, m...

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AL-amyloidosis in monoclonal gammopathies.

Sixty-two patients affected by MGUS underwent fat tissue aspirate examination for diagnosis of AL amyloidosis. Nine out of the 62 were found to be Congo red positive. MGUS had already been diagnosed for quite a long time in about 60% of these patients, while this prevalence decreased to 24% among the Congo red negative patients. The follow-up of the positive patients is reported.

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Monoclonal gammopathies in chest disease.

Monoclonal gammopathies are found in patients with myeloma, lymphoid malignant disorders, and amyloidosis. They are also discovered in patients with other diseases, and even in healthy people over 70 years.' 2 In such cases monoclonal gammopathies are of undetermined significance, and therefore of little if any diagnostic value. The aim of the present study was to evaluate the monoclonal gammop...

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 1982

ISSN: 0021-9746

DOI: 10.1136/jcp.35.1.63